The Association Between the Multiple Sclerosis Screening Questionnaire and Objective Measures of Cognition: A Systematic Literature Review and Meta-Analysis

Journal of Clinical and Experimental Neuropsychology

Tunmore, J., Kontou, E., et al. (2023).

Journal of Clinical and Experimental Neuropsychology, 45(2), 197-217.

<div>This systematic review and meta-analysis investigates the correlation between the Multiple Sclerosis Neuropsychological Questionnaire (MSNQ) and object measures of cognition, mood, and quality of life (QoL) for individuals with multiple sclerosis (MS).&nbsp;</div>

Health Education England

From database inception to July 16, 2022

<div>All study designs excluding reviews and meta-review/analysis papers</div>

15

<div>Meta-analysis revealed the following correlations between the MSNQ and objective measures for individuals with MS:</div> <div> <ul> <li><strong>Cognition:&nbsp;</strong>There was a significant, small association between the MNSQ and measures of cognition (r = -0.17).</li> <li><strong>Mood: </strong>There was a moderate, significant association between the MSNQ and measures of mood (r = 0.47).</li> <li><strong>QoL:</strong> One study reported a small to moderate association between the MSNQ and World Health Organization QoL (WHOQOL) scores for individuals with progressive MS (physical health [r = 0.165], psychological [r = 0.445], social relationship [r = 0.213], environment [r = 0.294]) and relapsing MS (physical health [r = 0.59], psychological [r = -0.467], social [r = 0.362], environment [r = 0.367]).</li> </ul> <div>Overall, this review indicated that the MSNQ did not coordinate well with objective measures of cognition, with modest correlations between the MSNQ and measures of mood and QoL.</div> <div>&nbsp;</div> <div>Limitations to this review include the lack of exploration of patient characteristics and their impact of assessment outcomes, potential for bias within self-reported measures, publication bias, and a lack of studies investigating QoL measures. Additional research is indicated.&nbsp;</div> </div>