Outcomes of Cochlear Implantation for the Patients With Specific Genetic Etiologies: A Systematic Literature Review
Acta Otolaryngologica
Nishio, S. Y., & Usami, S. I. (2017).
Acta Otolaryngologica, 137(7), 730-742.
This systematic review investigates the effect of cochlear implantation on outcomes in patients with profound sensorineural hearing loss due to genetic etiologies.
Ministry of Health, Labour and Welfare (Japan); Japan Agency for Medical Research and Development (AMED); Ministry of Education, Culture, Sports, Science and Technology (Japan)
April 1996-December 2016
Not further specified
86
Based on limited number of reports, cochlear implant outcomes for individuals with hearing loss due underlying genetic etiologies were found to be:<ul> <li>beneficial for the following genetic mutations: GJB2, SLC26A, CDH23, OTOF, mitochondrial, COCH, and ACTGI;</li> <li>beneficial with additional training or habilitation for Usher syndrome; and</li> <li>inconsistent outcomes for the following genetic mutations: GJB2, TMPRSS3, and Waardenburg syndrome.</li></ul>"To progress toward more solid evidence-based [cochlear implant] CI intervention, a greater number of reports including CI outcomes for specific gene mutations are desired" (p. 12).
