High-Frequency Repetitive Transcranial Magnetic Stimulation (HF-rTMS) Impacts Activities of Daily Living of Patients With Post-Stroke Cognitive Impairment: A Systematic Review and Meta-Analysis

Neurological Sciences

Chen, X., Liu, F., et al. (2023).

Neurological Sciences, 44(8), 2699-2713.

This study investigates the effects of high‑frequency repetitive transcranial magnetic stimulation (HF‑rTMS) combined with routine treatment on ADLs for individuals with post-stroke cognitive impairment.

Provincial College Students Innovation and Entrepreneurship Training Program (China)



From database inception to November 2022

Randomized-controlled trials

41 in the qualitative analysis; 34 in the meta-analysis

Ten studies investigated the added effect of HF-rTMS on ADLs using the total score of the Barthel Index and showed it was significantly higher than the control group (MD =10.39, 95% CI: 7.81 to 12.96, p<0.00001). Heterogeneity of stimulation parameters was a limitation.

The total score on the Modified Barthel Index in the HF-rTMS group was significantly higher than that in the control group (MD = 9.38, 95% CI: = 7.19 to  11.58, p < 0.00001). Heterogeneity of stimulation parameters was a limitation.

Functional Independence Measures in the HF-rTMS group were higher than that in the control group (MD =4.18, 95% CI: 0.20 to 8.16, p=0.04). Heterogeneity of stimulation parameters was a limitation.