Constraint and Multimodal Approaches to Therapy for Chronic Aphasia: A Systematic Review and Meta-Analysis

Neuropsychological Rehabilation

Pierce, J. E., Menahemi-Falkov, M., et al. (2019).

Neuropsychological Rehabilation, 29(7), 1005-1041.

This systematic review and meta-analysis investigates the efficacy and comparative effects of constraint-induced language treatment and multimodal treatment on language impairment, communication activity/participation, caregiver burden and quality of life in adults with chronic (at least six months) post-stroke aphasia.

Australian Government Research Training Program Scholarship


The data in this systematic review were also included elsewhere in the Evidence Maps. See the Associated Article(s) section for more information.

Up to September 2015; additional detail on p. 1013

Experimental studies (e.g., group design, single-subject design)

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Evidence examining the effect of constraint-induced and multimodal treatment for individuals with chronic aphasia was limited. Neither method was found to be superior over the other for improving communication outcomes. No studies examined quality of life or caregiver burden. Additionally, there was variation and ambiguity in what constitutes 'constraint', and evidence was variable for different communication modalities. As such, a meta-analysis was not conducted. The authors indicated that while the results were encouraging, the evidence is insufficient for any firm conclusions.