Computerized Cognitive Training in Multiple Sclerosis: A Systematic Review and Meta-Analysis
Neurorehabilitation & Neural Repair
Lampit, A., Heine, J., et al. (2019).
Neurorehabilitation & Neural Repair, 33(9), 695-706.
This systematic review and meta-analysis investigates the effects of computerized cognitive training for individuals with multiple sclerosis (MS). This review explores cognitive, functional, and psychosocial outcomes.
National Health and Medical Research Council (Australia); Australian Rotary Health scholarship
From database inception to March 9, 2019
Randomized-controlled trials
20
<div>Computerized cognitive training had a moderate, statistically significant effect on cognition (g = 0.30). Statistically significant improvements were noted in the following untrained domains:</div>
<ul>
<li><strong>Attention and processing speed: </strong>There was a moderate effect (g = 0.32).</li>
<li><strong>Executive functioning:</strong> There was a small effect (g = 0.29).</li>
<li><strong>Verbal learning and memory: </strong>There was a small effect (g = 0.28).</li>
<li><strong>Nonverbal learning and memory: </strong>There was a small effect (g = 0.21).</li>
</ul>
<div>Small, statistically insignificant effects were noted for working memory, psychosocial functioning, functional outcomes, and fatigue. At long-term follow-up, small, non-significant effects were noted for overall cognition, psychosocial function, fatigue, and functional outcomes. Future research should include larger sample sizes, longitudinal data, and individuals with progressive forms of MS.</div>
