Treatment of Progressive Multiple Sclerosis: What Works, What Does Not, and What Is Needed
The Lancet Neurology
Feinstein, A., Freeman, J., et al. (2015).
The Lancet Neurology, 14(2), 194-207.
This systematic review investigates the available treatments for a variety of symptoms (including cognitive dysfunction) in individuals with secondary progressive multiple sclerosis (MS).
Not stated
1994-2014
Any study type
30 total, 2 examining cognitive treatment
<div>Overall, there is insufficient evidence regarding cognitive retraining in individuals with secondary progressive MS. Two randomized control trials (one a replication of the other) examined cognitive retraining in a mixed population of individuals with secondary progressive MS and those with relapsing and relapsing remitting MS. Both reported positive effects, with the greatest benefit coming from interventions using context and imagery to improve new learning. Due to the lack of follow-up data, lack of functional outcomes, and data skewed toward individuals with relapsing remitting MS, further research is warranted.</div>
