Systematic Review and Meta-Analysis of the Clinical Utility of the ADOS-2 and the ADI-R in Diagnosing Autism Spectrum Disorders in Children
Journal of Autism and Developmental Disorders
Lebersfeld, J. B., Swanson, M., et al. (2021).
Journal of Autism and Developmental Disorders, 51(11), 4101-4114.
This systematic review and meta-analysis investigates the accuracy of the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) and the Autism Diagnostic Interview, Revised (ADI-R) in clinical settings for children suspected of being on the autism spectrum.
Not stated
2003 to 2018
Peer-reviewed studies with prospective, retrospective, cross-sectional, or longitudinal study designs excluding case studies and case series.
22
Superior accuracy was noted for the ADOS-2 when compared to the ADI-R for use in clinical settings with children suspected of being on the autism spectrum. ADOS-2 sensitivity ranged from 0.89-0.92, while its specificity ranged from 0.81-0.85. Mixed results were noted when comparing the accuracy of the ADOS-2 in clinical versus research settings, however differences in accuracy between settings were generally not significant. ADI-R sensitivity was noted to be 0.75, while its specificity was 0.82. Specificity for the ADI-R was reduced in clinical (0.72) versus research (0.85) settings, however sensitivity did not differ between settings. Limitations to this review include heterogeneity between studies and significant risk of bias regarding patient selection and reference standards within studies.
