Effectiveness of Language Training and Non-invasive Brain Stimulation on Oral and Written Naming Performance in Primary Progressive Aphasia: A Meta-Analysis and Systematic Review

Neuroscience and Biobehavioral Reviews

Cotelli, M., Manenti, R., et al. (2019).

Neuroscience and Biobehavioral Reviews, 108, 498-525.

This systematic review and meta-analysis investigates the use of language treatment alone compared to language treatment plus non-invasive brain stimulation (e.g., transcranial direct current stimulation, or tDCS) to improve oral and written naming abilities in individuals with primary progressive aphasia (PPA).

Italian Ministry of Health



Through May 31, 2019

Original research studies

43 studies on language treatment alone; 7 studies on language treatment combined with non-invasive brain stimulation

<div>For individuals with PPA, pooled findings revealed the following:</div> <div> <ul> <li>Language training alone improved naming for trained items (SMD = 0.48)</li> <li>Language training combined with tDCS improved non-word naming abilities for trained (SMD = 0.3) and untrained items (SMD = 0.14).&nbsp;</li> <li>Overall, there was no significant difference in outcomes for language training alone or language training plus tDCS.</li> </ul> </div>