The Role of Vestibular Evoked Myogenic Potentials in Multiple Sclerosis-Related Vertigo. A Systematic Review of the Literature

Multiple Sclerosis and Related Disorders

Di Stadio, A., Dipietro, L., et al. (2019).

Multiple Sclerosis and Related Disorders, 28, 159-164.

This systematic review investigates the use of vestibular evoked myogenic potentials (VEMPs) to assess and monitor symptoms of balance disorder (e.g., vertigo, dizziness) in patients with multiple sclerosis (MS).

No funding received



From 1960 to the first trimester of 2018

Case reports; case series; epidemiological studies; case-control studies; prospective studies; retrospective studies.

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<div>For individuals with MS and symptoms of vertigo, 20 articles investigating the use of VEMPs to measure vestibular symptoms reported significant correlation (p &lt; 0.001) between vertigo and increased VEMP latencies and significant correlation (p&lt;0.05) between VEMP alteration (increased amplitude and prolonged latency) and presence of white matter hyperintensities in the vestibular central pathway. The findings suggest that "VEMPs could be used to evaluate the integrity of vestibular pathways and particularly of the inferior vestibular nerve in patients with MS with vertigo ... Because of their high sensitivity, VEMPs are potentially suitable to aid in both the diagnosis and monitoring of disease progression" (p. 163).</div>